Catarina Bombaça – AIM Fellow 2018

Catarina Bombaça_foto 2018

Catarina Bombaça has a bachelor degree in Biochemistry from the Faculty of Sciences and Technology of New University of Lisbon and a master degree in Biotechnology from Instituto Técnico of University of Lisbon.

Her PD-FCT AIM project is entitled “Microfluidic liquid chromatography: point-of-use analysis of complex solutions (LC-Chip)”. This project takes place at INESC-MN and IBB. The thesis is supervised by João Pedro Conde (INESC-MN and  Department of Bioengineering of Técnico) and co-supervised by Ana Azevedo (IBB). Her doctoral program started on November 1st 2018.

Project goals

TASK 1 – TECHNOLOGY DEVELOPMENT . This task focuses on the microfabrication of the prototype LC-Chip, which will have a separation column, a mobile phase injector, a sample injector, and integrated detection at the column outlet.

TASK 2 – OPTIMIZATION IN MODEL SYSTEMS . The microfluidic device developed in TASK 1 will be evaluated in a series of increasingly demanding tests. In some of these tests, systems of practical relevance are used to make a link with potential applications of the LC-Chip.

TASK 3 – APPLICATION CASES . The same analytes tested in model solutions in TASK 2 will be tested in the presence of complex matrices (such as solutions from different stages of grape maturation and wine production or fetal bovine serum). In an initial stage, the analytes will be spiked in the complex matrices. In a second stage the original analyte concentrations in the complex matrix will be measured.