• Researcher of the Biological Sciences Research Group

• Ph.D. in Biotechnology (supervision: I. Sá-Correia), IST, UTL, 2010

• Graduation in Biological Engineering, Instituto Superior Técnico, Technical University of Lisbon, Portugal, 2006

• Post-doc Researcher, IBB/CEBQ/BSRG, IST, 2011- present

• Ph.D student in Biotechnology, IBB/CEBQ/BSRG, IST, 2006-2010

• Microbial physiology and molecular biology
• Functional genomics, chemogenomics, transcriptomics and proteomics
• Study of antibiotic resistance and chronic infection mechanisms in Burkholderia cepacia complex bacteria
• Bacterial molecular epidemiology and adaptation to environmental stress conditions

• Post-doc Scolarship from "Fundação para a Ciência e Tecnologia" (SFRH/BPD/75483/2010).

• PhD Scolarship from "Fundação para a Ciência e Tecnologia" (SFRH/BD/32479/2006).

dos Santos, S.C. (2010). Yeast as a model in Pharmacogenomics: targets and mechanisms of resistance to imatinib and quinine. Ph.D. in Biotechnology, Instituto Superior Técnico.

dos Santos, S.C. (2006). The effect of antimicrobial peptides on genome integrity in yeast and the relatioship with involved apoptosis. Erasmus at the Centre for Biomolecular Sciences, St Andrews University, UK. Thesis in Biological Engineering, Instituto Superior Técnico.

Papers in peer-reviewed international journals

dos Santos, S.C., Mira, N.P., Moreira, A.S., Sá-Correia, I., Quantitative- and phospho-proteomic analysis of the yeast response to the tyrosine kinase inhibitor imatinib. OMICS: A Journal of Integrative Biology, accepted for publication.

dos Santos, S.C., Teixeira, M.C., Cabrito, T.R., Sá-Correia, I., Yeast Toxicogenomics: genome-wide responses to chemical stresses with impact in Environmental Health, Pharmacology and Biotechnology. Frontiers in Genetics, 3, 63, 2012.

C.P. Coutinho, S.C. dos Santos, A. Madeira, N.P. Mira, A.S. Moreira, I. Sá-Correia, “Long-term colonization of the cystic fibrosis lung by Burkholderia cepacia complex bacteria: epidemiology, clonal variation, and genome-wide expression alterations”, Frontiers in Cellular Infection and Microbiology, 1, 1-11, 2011.  

S.C. dos Santos, I. Sá-Correia, “A genome-wide screen identifies yeast genes required for protection against or enhanced toxicity of the antimalarial drug quinine”, Molecular Genetics and Genomics, 286, 333-346, 2011.

D. Abdulrehman, P.T. Monteiro, M.C. Teixeira, N.P. Mira, A.B. Lourenço, S.C. dos Santos, T.R. Cabrito, A. Francisco, S.C. Madeira, R. Santos, A.L. Oliveira, I. Sá-Correia, A.T. Freitas, “YEASTRACT: Providing a programmatic access to curated transcriptional regulatory associations in Saccharomyces cerevisiae through a web services interface.” Nucleic Acids Research, 39, D136-140, 2011

S.C. dos Santos, S. Tenreiro, M. Palma, J. Becker, I. Sá-Correia, “Transcriptomic profiling of the yeast response to quinine evidenced a glucose limitation response attributable to drug-induced inhibition of glucose uptake”, Antimicrobial Agents and Chemotherapy , 53, 5213-5223, 2009 (abstract)

S.C. dos Santos, I. Sá-Correia, "Genome-wide identification of genes required for yeast growth under imatinib stress: vacuolar H⁺-ATPase function is an important target of this anticancer drug", OMICS: A Journal of Integrative Biology, 13: 185-198, 2009 (abstract)

I. Sá-Correia, S.C. dos Santos, M.C. Teixeira, T.R. Cabrito, N.P. Mira, "Drug:H+ antiporters in chemical stress response in yeast". Trends in Microbiology, 17, 22-31, 2009 (abstract)

C.O. Morton, S.C. dos Santos, P. Coote, "An amphibian-derived, cationic, alpha-helical antimicrobial peptide kills yeast cells by caspase-independent but AIF-dependent programmed cell death", Molecular Microbiology, 65(2): 494-507 (2007) (abstract)

Abstracts in international meetings

S. C. dos Santos, S. Tenreiro, M. Palma and I. Sá-Correia, "Transcriptomic profiling of the yeast response to quinine evidenced a glucose limitation response attributable to glucose uptake inhibition by quinine", 27th ISSY – Yeasts for health and biotechnologies, 26 – 29 August, Paris, France. 

S. C. dos Santos and I. Sá-Correia, "Genome-wide identification of genes required for growth of yeast cells challenged with the anticancer drug imatinib: new targets and mechanisms of resistance", 27th ISSY – Yeasts for health and biotechnologies, 26 – 29 August, Paris, France. (Oral communication)

S.C. dos Santos, S. Tenreiro, J. Becker and I. Sá-Correia, “Evidence for a carbon limitation response to quinine in yeast due to glucose uptake inhibition, as suggested by a transcriptional and susceptibility phenotype profiling”, 26th Small Meeting on Yeast Transport and Energetics, 6-9 September, Braga, Portugal. (Oral communication)

S.C. dos Santos and I. Sá-Correia, “A genome-wide screen of Saccharomyces cerevisiae disruptome identified novel Imatinib targets and genes conferring resistance to this drug”, Yeast Genetics and Biomolecular Biology Meeting 2008, 22-27 July, Toronto, Canada.

S.C. dos Santos, S. Tenreiro, J. Becker and I. Sá-Correia, “Integrating transcriptional and susceptibility phenotype profiling to understand the early response to stress induced by quinine in yeast”, Yeast Genetics and Biomolecular Biology Meeting 2008, 22-27 July, Toronto, Canada. (Oral communication)

P.T. Monteiro, M.C. Teixeira, N.P. Mira, N.D. Mendes, A.B. Lourenço, A.P. Francisco, T.R. Cabrito, S.C. dos Santos, I. Sá-Correia, A.L. Oliveira and A.T. Freitas “YEASTRACT, an information system for the analysis of transcription regulatory associations in Saccharomyces cerevisiae”, Yeast Genetics and Biomolecular Biology Meeting 2008, 22-27 Julho, Toronto, Canada.

Abstracts in national meetings

S. C. dos Santos and I. Sá-Correia, "Genome-wide identification of genes required for growth of yeast cells challenged with the anticancer drug imatinib: new targets and mechanisms of resistance", XVII Jornadas de Biologia de Leveduras Professor Nicolau van Uden, 19 - 20 June, Braga, Portugal. (Oral communication)

S.C. dos Santos and I. Sá-Correia, "Identification of novel imatinib targets and mechanisms of resistance in chronic myeloid leukaemia, using the eukaryotic model Saccharomyces cerevisiae: a genome-wide screen of the yeast disruptome", MICROBIOTEC'07, 30 Nov - 2 Dec 2007, Lisbon, Portugal.