SANDRA SOFIA COSTA DOS SANTOS

(Post-doc researcher) *

Alternative Pages: Google Scholar; Research ID; iBB webpage

Status at iBB - Institute for Bioengineering and Biosciences:  

·         Researcher of the Biological Sciences Research Group

Education:

  • Ph.D. in Biotechnology (supervision: I. Sá-Correia), IST, UTL, 2010

  • Graduation in Biological Engineering, Instituto Superior Técnico, Technical University of Lisbon, Portugal, 2006

Positions:       

  • Post-doc Researcher, IBB/CEBQ/BSRG, IST, 2011- present

  • Ph.D student in Biotechnology, IBB/CEBQ/BSRG, IST, 2006-2010

Research Activities:       

  • Next Generation Sequencing (NGS) data analysis and Comparative Genomics

  • Clinical molecular epidemiology

  • Functional genomics and microbial physiology

  • Yeast as an eukaryotic model

  • Post-genomic approaches applied to stem cell engineering

Grants:        

  • Post-doc Scolarship from "Fundação para a Ciência e Tecnologia" (SFRH/BPD/75483/2010)

  • PhD Scolarship from "Fundação para a Ciência e Tecnologia" (SFRH/BD/32479/2006)

Awards:        

  • Alfagene Award for Young Researcher in Microbiology, awarded at the Congress of Microbiology and Biotechnology 2015, Portugal

  • Best Poster Award, granted by the European Cystic Fibrosis Society at the 36th European Cystic Fibrosis Conference, 2013

  • Young Researcher Award SPM - Isabel Spencer-Martins, awarded by the Portuguese Society of Microbiology, 2012

Selected Publications:

Thesis:

dos Santos, S.C. (2010). Yeast as a model in Pharmacogenomics: targets and mechanisms of resistance to imatinib and quinine. Ph.D. in Biotechnology, Instituto Superior Técnico.

dos Santos, S.C. (2006). The effect of antimicrobial peptides on genome integrity in yeast and the relatioship with involved apoptosis. Erasmus at the Centre for Biomolecular Sciences, St Andrews University, UK. Thesis in Biological Engineering, Instituto Superior Técnico.


Papers in international journals

 

Moreira, A.S., Mil-Homens, D.*, Sousa, S.A.*, Coutinho, C.P.*, Pinto-de-Oliveira, A., Ramos, C.G., dos Santos, S.C., Fialho, A.M., Leitão, J.H., Sá-Correia, I., Variation of Burkholderia cenocepacia virulence potential during cystic fibrosis chronic lung infection. Virulence, doi:10.1080/21505594.2016.1237334 (in press).

dos Santos, S.C., Sá-Correia, I., "Yeast toxicogenomics: lessons from a eukaryotic cell model and cell factory", Current Opinion in Biotechnology 33:183–191, 2015.

dos Santos, S.C., Teixeira, M.C., Dias, P.J., Sá-Correia, I., "MFS transporters required for multidrug/multixenobiotic (MD/MX) resistance in the model yeast: understanding their physiological function through post-genomic approaches", Frontiers in Physiology, 5:180, 2014.

Teixeira, M.C., Monteiro, P.T., Guerreiro, J.F., Gonçalves, J.P., Mira, N.P., dos Santos, S.C., Cabrito, T., Palma, M., Costa, C., Francisco, A.P., Madeira, S.C., Oliveira, A.L., Freitas, A.T., Sá-Correia, I., The YEASTRACT database: an upgraded information system for the analysis of gene and genomic transcription regulation in Saccharomyces cerevisiae, Nucleic Acids Research, 42: D161-D166, 2014.

Madeira, A., dos Santos, A.C., Santos, P.M., Coutinho, C.P., Tyrrell, J., McClean, S., Callaghan, M., Sá-Correia, I., Proteomic profiling of Burkholderia cenocepacia clonal isolates with different virulence potential retrieved from a cystic fibrosis patient during chronic lung infection, PLOS ONE 8(12): e83065, 2013.

dos Santos, S.C., Mira, N.P., Moreira, A.S., Sá-Correia, I., Quantitative- and phospho-proteomic analysis of the yeast response to the tyrosine kinase inhibitor imatinib. OMICS: A Journal of Integrative Biology, 16: 537-51, 2012.

dos Santos, S.C., Teixeira, M.C., Cabrito, T.R., Sá-Correia, I., Yeast Toxicogenomics: genome-wide responses to chemical stresses with impact in Environmental Health, Pharmacology and Biotechnology. Frontiers in Genetics, 3, 63, 2012.

C.P. Coutinho, S.C. dos Santos, A. Madeira, N.P. Mira, A.S. Moreira, I. Sá-Correia, “Long-term colonization of the cystic fibrosis lung by Burkholderia cepacia complex bacteria: epidemiology, clonal variation, and genome-wide expression alterations”, Frontiers in Cellular Infection and Microbiology, 1, 1-11, 2011.  

S.C. dos Santos, I. Sá-Correia, “A genome-wide screen identifies yeast genes required for protection against or enhanced toxicity of the antimalarial drug quinine”, Molecular Genetics and Genomics, 286, 333-346, 2011.

D. Abdulrehman, P.T. Monteiro, M.C. Teixeira, N.P. Mira, A.B. Lourenço, S.C. dos Santos, T.R. Cabrito, A. Francisco, S.C. Madeira, R. Santos, A.L. Oliveira, I. Sá-Correia, A.T. Freitas, “YEASTRACT: Providing a programmatic access to curated transcriptional regulatory associations in Saccharomyces cerevisiae through a web services interface.” Nucleic Acids Research, 39, D136-140, 2011

S.C. dos Santos, S. Tenreiro, M. Palma, J. Becker, I. Sá-Correia, “Transcriptomic profiling of the yeast response to quinine evidenced a glucose limitation response attributable to drug-induced inhibition of glucose uptake”, Antimicrobial Agents and Chemotherapy, 53, 5213-5223, 2009 (abstract)

S.C. dos Santos, I. Sá-Correia, "Genome-wide identification of genes required for yeast growth under imatinib stress: vacuolar H+-ATPase function is an important target of this anticancer drug", OMICS: A Journal of Integrative Biology, 13: 185-198, 2009 (abstract)

I. Sá-Correia, S.C. dos Santos, M.C. Teixeira, T.R. Cabrito, N.P. Mira, "Drug:H+ antiporters in chemical stress response in yeast". Trends in Microbiology, 17, 22-31, 2009 (abstract)

C.O. Morton, S.C. dos Santos, P. Coote, "An amphibian-derived, cationic, alpha-helical antimicrobial peptide kills yeast cells by caspase-independent but AIF-dependent programmed cell death", Molecular Microbiology, 65(2): 494-507, 2007 (abstract)