Sílvia Henriques

(PhD Student) *

Alternative Pages: Google Scholar; Research ID; iBB webpage

Status at iBB - Institute for Bioengineering and Biosciences:

·         Researcher of the Biological Sciences Research Group

Education:

  • Graduation in Biochemistry, Faculty of sciences of the University of Lisbon, Portugal, 2008

  • Master degree in Biotechnology, Instituto Superior Técnico, Technical University of Lisbon, Portugal, 2010

Positions:

  • Graduate fellow at IBB/CEBQ/BSRG, IST, under the supervision of professor Isabel Sá-Correia, 2010-present

Research Activities:

  • Yeast physiology and Molecular Biology

  • Molecular mechanisms of Saccharomyces cerevisiae adaptation to weak acids-induced stress

  • Functional and structural characterization of the interaction of Saccharomyces cerevisiae transcription factor Haa1 with its target DNA sequence

Grants:

  • Research grant from "Fundação para a Ciência e Tecnologia (PTDC/EBB-EBI/108517/2008)

Publications:

Thesis

Henriques, S.H., The Yeast Transcription Factor Haa1p: identification of amino acid residues and nucleotides essential for functional Haa1-DNA association, in Instituto Superior Técnico, Universidade Técnica de Lisboa, Lisboa, 2010

Papers in international journals

Henriques, S.F., Mira, N.P., Sá-Correia, I., Genome-wide search for candidate genes for yeast robustness improvement against formic acid reveals novel susceptibility (Trk1 and positive regulators) and resistance (Haa1-regulon) determinants, Biotechnology for Biofuels, in press.

Swinnen, S.*, Henriques, S.C.F.*, Shrestha, R., Ho, P.W., Sá-Correia, I.**, Nevoigt, E.**, Improvement of yeast tolerance to acetic acid through Haa1 transcription factor engineering: towards the underlying mechanisms, Microbial Cell Factories, 16:7, 2017. (*co-first;**co-correspondent)

Rodrigues, R.M.M., de Carvalho, J., Henriques, S.F., Mira, N.P., Sá-Correia, I., Ferreira, G.N.M., "Transmission Line Model Analysis of Transcription Factors Binding to Oligoduplexes - Differentiation of the Effect of Single Nucleotide Modifications", Analyst, 139(16):3871-4, 2014.

de Carvalho, J., Rodrigues, R.M.M., Tomé, B., Henriques, S.F., Mira, N.P., Sá-Correia, I., Ferreira, G.N.M., Conformational and Mechanical changes of DNA upon transcription factor binding detected by a QCM and transmission line model, Analyst, 139(8):1847-55, 2014.

Mira, N.P., Henriques, S., Keller, G., Teixeira, M.C., Matos, R., Arraiano, C., Winge, D.R., Sá-Correia, I., Identification of a DNA binding site for the transcription factor Haa1p, required for Saccharomyces cerevisiae response to acetic acid stress. Nucleic Acids Research, 16, 6898-907, 2011.

 

Abstracts in national meetings

Mira, N.P., Santos, S.C., Teixeira, M.C., Cabrito, T.R., Palma, M., Lourenço, A.B., Dias, P.J., Guerreiro, J., Moreira, A., Henriques, S.F., Sá-Correia, I., Response and Resistance to Drugs and Chemical Stress in the Yeast Model: a Genome-¬Wide View. 1st National Meeting on Bioengineering, Oeiras, 1-4 March, 2011

Santos, S.C., Teixeira, M.C., Mira, N.P., Cabrito, T.R., Palma, M., Lourenço, A.B., Dias, P.J., Guerreiro, J., Moreira, A., Henriques, S.F., Sá-Correia, I., Response and Resistance to Drugs and Chemical Stress in the Yeast Model: a Genome-¬Wide View. 1st portuguese meeting in Bioengineering, 1-4th March, Oeiras, Portugal (also selected for oral presentation)