Paulo Jorge Costa Dias

(Post-Doc Researcher) *

Alternative Pages: Google Scholar; Research ID; iBB webpage

Status at iBB - Institute for Bioengineering and Biosciences:

Education:

  • Currently is a fourth year PhD student at Biological Sciences Research Group, Institute for Biotechnology and Bioengineering (IBB), under the supervision of Prof. Isabel Sá-Correia

  • 2005 - Master degree on Probability and Statistics by Faculty of Sciences of the Lisbon University (Portugal), with maximal classification.

  • 2001 - Graduation degree on Microbial Biology and Genetics by Faculty of Sciences of the Lisbon University (Portugal), with a final classification of 16 over 20.

Positions:

  • Ph.D. Student in Biotechnology, IST, UTL, since 2006

Present Research Interests:

  • “Omics” approaches to yeast physiology

  • Bioinformatics.

  • Response to environmental stress in S. cerevisiae

  • Characterization of transcriptional regulatory networks associated with multidrug resistance (MDR).

  • MDR-MFS transporters: their identification and characterization of phylogenetic cluster specific protein motifs

Grants:

  • PhD Scolarship from "Fundação para a Ciência e a Tecnologia" (SFRH/BD/23331/2005)

Publications:

Thesis

Dias P.J., Taxonomic analysis in Candida albicans: from isolation and phenotypic identification to molecular typing, Graduation in Biology Thesis, Faculty of Sciences of the Lisbon University, 2001

Dias P.J.,  Transmembrane proteins topology prediction: non-homogenous hidden Markov models under a Bayesian perspectiv, Master Thesis in Probability and Statistics, Faculty of Sciences of the Lisbon University, 2005


Papers in international journals

Palma, M., Dias, P.J., Roque, F.C., Luzia, L., Guerreiro, J.F., Sá-Correia, I., The Zygosaccharomyces bailii transcription factor Haa1 is required for acetic acid and copper stress responses suggesting subfunctionalization of the ancestral bifunctional protein Haa1/Cup2, BMC Genomics, in press.

Costa, C., Dias, P.J., Sá-Correia, I., Teixeira, M.C., "MFS multidrug transporters in pathogenic fungi: do they have real clinical impact?", Frontiers in Physiology, 5:197, 2014.

Dias P.J., Sá-Correia I., "Phylogenetic and syntenic analyses of the 12-spanner drug:H(+) antiporter family 1 (DHA1) in pathogenic Candida species: evolution of MDR1 and FLU1 genes". Genomics, 104(1):45-57, 2014.

dos Santos, S.C., Teixeira, M.C., Dias, P.J., Sá-Correia, I., "MFS transporters required for multidrug/multixenobiotic (MD/MX) resistance in the model yeast: understanding their physiological function through post-genomic approaches", Frontiers in Physiology, 5:180, 2014.

Dias, P.J., Sá-Correia, I., The drug:H+ antiporters of family 2 (DHA2), siderophore transporters (ARN) and glutathione:H+ antiporters (GEX) have a common evolutionary origin in hemiascomycete yeasts, BMC Genomics, 14: 901, 2013.

Monteiro, P.T., Dias, P.J., Ropers, D., Oliveira, A.L., Sá-Correia, I., Teixeira, M.C., Freitas, A.T., 2010, "Qualitative modeling and formal verification of the FLR1 gene mancozeb response in Saccharomyces cerevisiae", IET Systems Biology. 5(5):308-16, 2011.

Teixeira M.C., Dias P.J., Monteiro P.T., Sala A., Oliveira A.L., Freitas A.T., Sá-Correia I., 2010, "Refining current knowledge on the yeast FLR1 regulatory network by combined experimental and computational approaches", Molecular Biosystems, 6:2471-81, 2010.

Dias P.J., Seret, M.-L., Goffeau, A., Sá-Correia, I., Baret, P.V., "Evolution of the 12-spanner drug:H+ antiporter DHA1 family in hemiascomycetous yeasts", OMICS: A Journal of Integrative Biology, 14: 701-10, 2010.

Dias P.J., Teixeira M.C., Telo J.P., Sá-Correia I., 2010, "Insights into the mechanisms of toxicity and tolerance to the agricultural fungicide mancozeb in yeast, as suggested by a chemogenomic approach", OMICS: A Journal of Integrative Biology, 14:211-27, 2010.

Teixeira, M.C.; Dias, P.J.; Simões, T. & Sá-Correia, I., (2008), "Yeast adaptation to mancozeb involves the up-regulation of FLR1 under the coordinate control of Yap1, Rpn4, Pdr3 and Yrr1", Biochemical Biophysical Research Communications. 367: 249-255  (abstract)

Abstracts in national and international meetings

Oral Communications

Ramos, C.G., Sousa, S.A., Grilo, A.M., da Costa, P.J.P., Feliciano, J.R, Leitão, J.H., A RNomics-based strategy identifies regulatory small RNAs in Burkholderia cenocepacia complex. First Portuguese Meeting in Bioengineering – IEEE-EMBS, 1-4 March 2011, IST, TagusPark, Oeiras, Portugal

Dias P.J., Seret M.-L., Goffeau A., Sá-Correia I. and Baret P., "Evolution of the 12-spanner drug:H+ antiporter DHA1 family in hemiascomycete yeasts", XVIII Jornadas de Biologia de Leveduras “Nicolau van Uden”, Lisboa, 18-19 June, 2010.

Teixeira M.C., Monteiro P.T., Dias P.J., Costa C.P., Ropers D., Oliveira A.L., Freitas A.T. and Sá-Correia I., Refining current knowledge on the regulatory network underlying the transcriptional control of the multidrug resistance gene FLR1 combining experimental and computational approaches, XVIII Jornadas de Biologia de Leveduras “Nicolau van Uden”, Lisboa, 18-19 June, 2010.

Dias P.J., Teixeira M.C., Santos P.M., Telo J.P., Lourenço A.B., Sá-Correia I., "Mechanistic insights into the response and resistance to the agricultural fungicide mancozeb using Omics approaches", 4th Conference on Physiology of Yeast and Filamentous Fungi (PYFF4), Rotterdam, 1-4 June, 2010.

Dias P.J., Telo J.P., Teixeira M.C., Sá-Correia I., "Use of chemogenomics to identify genes involved in yeast resistance to the agricultural fungicide mancozeb", XVII Jornadas de Biologia de Leveduras “Nicolau van Uden”, Braga, 19-20 June, 2009.

Teixeira M.C., Dias P.J., Simões T. and Sá-Correia I., Coordinate control of the transcriptional up-regulation of FLR1 in yeast response to the fungicide mancozeb involves Yap1p, Pdr3p, Yrr1p and Rpn4p, SMYTE26, Braga, 6-9 September, 2008.

Written Communications

Monteiro, P.T., Dias, P.J., Ropers, D., Oliveira, A.L., Sá-Correia, I., Teixeira, M.C., Freitas, A.T., Computational modeling and analysis of the Yeast FLR1 Regulatory Network in Mancozeb-challenged Cells, 11th International Conference on Systems Biology, Edinburgh, 10-15 October, 2010.

Teixeira M.C., Monteiro P.T., Dias P.J., Costa C.P., Ropers D., Oliveira A.L., Freitas A.T. and Sá-Correia I., Refining current knowledge on the regulatory network underlying the transcriptional control of the multidrug resistance gene FLR1 combining experimental and computational approaches, XVIII Jornadas de Biologia de Leveduras “Nicolau van Uden”, Lisboa, 18-19 June, 2010.

Dias P.J., Seret M.-L., Goffeau A., Sá-Correia I. and Baret P., Evolution of the 12-spanner drug:H+ antiporter DHA1 family in hemiascomycete yeasts, 4th Conference on Physiology of Yeast and Filamentous Fungi (PYFF4), Rotterdam, 1-4 June, 2010.

Dias P.J, Teixeira M.C., Telo J.P. and Sá‐Correia I., Insights into the mechanisms of toxicity and tolerance to the thiol‐reactive agricultural fungicide mancozeb in yeast, as suggested by a chemogenomic approach, 138, Microbiotec09, Vilamoura, 28-30 November, 2009.

Teixeira M.C., Dias P.J., Simões T. and Sá-Correia I., Coordinate control of the transcriptional up-regulation of FLR1 in yeast response to the fungicide mancozeb involves Yap1p, Pdr3p, Yrr1p and Rpn4p, SMYTE26, Braga, 6-9 September, 2008.

Dias P.J., Santos P.M., Teixeira M.C., Simões T. and Sá-Correia I., Use of toxicogenomics and chemogenomics to identify genes involved in yeast response and resistance to the agricultural fungicide mancozeb, Yeast2008, 595A, Toronto, 22-27 July, 2008.

Lourenço A.B., Santos P.M., Dias P.J., Teixeira M.C., Simões T., Cabrito T.R., Ascenço J.R. and Sá-Correia I., New insights into the biological function of the drug-H+ antiporter encoded by the FLR1 gene revealed by H1-NMR-based metabolomics and expression proteomics, Yeast2008, 625A, Toronto, 22-27 July, 2008.

Simões T., Santos P.M., Dias P.J., Teixeira M.C. and Sá-Correia I., Insights into the mechanisms underlying yeast response and resistance to the fungicide mancozeb using expression proteomics and chemogenomics, Micro’07-Biotec’07-XXXIII JPG, S4/P15, Lisbon, 30 Nov – 2 Dez, 2007.

Teixeira M.C., Dias P.J., Simões T. and Sá-Correia I., Increased expression of the multidrug resistance transporter Flr1 in response to the fungicide mancozeb: the underlying transcriptional regulatory network, Micro’07-Biotec’07-XXXIII JPG, S2/P37, Lisbon, 30 Nov – 2 Dez, 2007.

Simões T., Santos P.M., Dias P.J., Teixeira M.C. and Sá-Correia I., Global analysis of the mechanism underlying yeast resistance and response to the fungicide mancozeb, 3rd Conference on Physiology of Yeasts and Filamentous Fungi (PYFF3), P26, Helsinki, June 13-16,  2007.

Dias P.J., Sousa L., Predição da topologia de proteínas transmembranares: modelos de Markov escondidos não-homogéneos numa perspectiva bayesiana, XIII Annual Conference of the Statistical Portuguese Society (SPE), Ericeira,  2005.

Dias P.J., Rosado M. L. and Tenreiro R., Tipificação de estirpes de Candida albicans e Candida parapsilosis utilizando as técnicas de MSP-PCR e PFGE, Micro2001, Póvoa do Varzim, Portugal.

Rosado L., Fernandes E., Veríssimo C., Loureiro M., Sousa L., Mira M.J., Dias P.J. and Brandão J., Epidemiological survey of Tinea capitis and introduction of molecular techniques in an elementary school in the outskirts of Lisbon during 1987/88 and 1998/99, 6th Medical Mycology European Congress, Barcelona, 2000.

Material Suplementar

Tabela Excel Ph.D.  (link)