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Miguel Nobre Parreira Cacho Teixeira(Assistant Professor) *
Status at
IBB
- Institute for Biotechnology and Bioengineering /
Centre for
Biological and Chemical Engineering (CEBQ):
·
Researcher of the
Biological Sciences
Research Group Education:
·
Graduation in Chemical
Engineering (Biotechnology), IST, UTL, Lisbon, Portugal, 2000
·
PhD in Biotechnology, CEBQ/BSRG, IST,
UTL, Lisbon, Portugal, 2004
Positions:
·
Assistant Professor, IST, 2008-present
·
Assistant Researcher, IBB-IST, 2008
(within the scope of Ciência 2007 program)
·
Invited Assistant Professor, IST,
2007-2008 (within the scope of the MIT-Portugal program)
·
Post-doctoral fellow, BSRG-IST, 2004-2007
Research
Activities:
·
Mechanisms of antifungal drug
resistance in Candida
glabrata
·
Yeast physiology and Molecular Biology · Environmental stress response · Proteomics and transcriptomics
·
Systems biology tools for the study of
transcriptional regulatory networks
Projects
as PI:
·
PTDC/EBB-BIO/119356/2010:
"FUNDRING: Identification of new biomarkers for antiFUNgal
Drug Resistance diagnosis IN Candida
Glabrata: the particular role of multidrug resistance
transporters". (2012-)
·
PTDC/BIA-MIC/72577/2006:
"Functional and biochemical analysis of the yeast multidrug resistance
transporters Qdr2 and Aqr1" (2007-2011).
·
PTDC/BIO/72063/2006: “Characterization
and modeling of a specific transcriptional regulatory network required for
multidrug resistance in yeast” (March-Sept 2010).
Awards:
·
Researcher award UTL/Santander
(honorable mention), 2011
·
Young Researcher in Microbiology award
SPM/Alfagene, 2009
·
Young Researcher award UTL/Deloitte,
2008, in the field of Biochemistry and Biotechnology
·
Sartorius award - Innovation in
Microbiology/Biotechnology , 2007
Selected Publications:
Book chapters:
Teixeira, M.C., "Complex
regulatory interplay between multidrug resistance and oxidative stress
response in yeast: the FLR1
regulatory network as a systems biology case-study", In:
Oxidative Stress - Molecular Mechanisms and Biological
Effects
(Lushchak
V.I.
& Semchyshyn H., Eds),
INTECH, Vienna, Austria,
323-340, 2012.
Mira, N.P., Teixeira, M.C.,
Sá-Correia, I., "Characterization of complex regulatory networks and
identification of promoter regulatory elements in yeast: in
silico and wet-lab", In: Methods in Molecular
Biology - Transcriptional Regulation: Methods and Protocols (Vancura A., Ed), Springer, vol. 809,
27-48, 2012. T.R.
Cabrito, E. Remy, M.C. Teixeira, P. Duque, I. Sá-Correia, "Resistance to
herbicides in the model organisms
Saccharomyces
cerevisiae and Arabidopsis thaliana: the involvement
of multidrug resistance transporters", In: Herbicides and Environment (Kortekamp A., Ed), INTECH, Vienna, Austria, 623-640, 2011 T.R. Cabrito, M.C. Teixeira, I. Sá-Correia, “Global adaptive response and resistance to agricultural fungicides: lessons from yeast and phytopathogenic fungi” In: Fungicides: Chemistry, Environmental Impact and Health Effects (Columbus F, Ed), Nova Science Publishers, New York, USA, p. 228-253, 2009. I.
Sá-Correia, M.C. Teixeira, "As complexas redes de regulação da
expressão genética na levedura: abordagens à escala do genoma". In:
O Mundo do RNA: Novos Desafios e
Perspectivas Futuras (Cecília
M. Arraiano, A.M. Fialho, Eds), Lidel Edições Técnicas, Lisboa, p. 223-242,
2006. dos Santos, S.C., Teixeira, M.C., Cabrito, T.R., Sá-Correia, I., Yeast Toxicogenomics: genome-wide responses to chemical stresses with impact in Environmental Health, Pharmacology and Biotechnology. Frontiers in Genetics, 3, 63, 2012. Remy, E., Cabrito, T.R., Baptista, R., Teixeira, M.C., Sá-Correia, I., Duque, P., The Pht1;9 transporter mediates inorganic Pi acquisition by the Arabidopsis thaliana root during phosphorus starvation. The New Phytologist, DOI: 10.1111/j.1469-8137.2012.04167.x .
Pereira, F.B., Guimarães, P.M.R., Gomes, D.G., Mira, N.P., Teixeira, M.C., Sá-Correia, I., Domingues, L., Identification of candidate genes for yeast engineering to improve bioethanol production in Very-High-Gravity and lignocellulosic biomass industrial fermentations, Biotechnology for Biofuels,
4, 57, 2011.
Gonçalves,
J.P., Francisco, A.P., Mira, N.P., Teixeira, M.C., Sá-Correia, I., Oliveira,
A.L., Madeira, S.C., TFRank: Network-based
prioritization of regulatory associations underlying transcriptional
responses, Bioinformatics,
27, 3149-3157, 2011.
Cabrito, T.R.,
Teixeira, M.C., Singh, A., Prasad, R., Sá-Correia, I., The yeast ABC
transporter Pdr18 (ORF YNR070w)
controls plasma membrane sterol composition, playing a role in multidrug
resistance, Biochemical Journal,
440, 195-202, 2011.
Monteiro P.T.,
Dias J.P., Ropers D., Oliveira A.L., Sá-Correia I., Teixeira M.C., Freitas
A.T., "Qualitative modeling and formal verification of the
FLR1 gene mancozeb
response in Saccharomyces cerevisiae",
IET Systems Biology,
5, 308-316,
2011.
Mira, N.P.,
Henriques, S., Keller, G., Teixeira, M.C., Matos, R., Arraiano,
C., Winge, D.R., Sá-Correia, I., Identification of
a DNA binding site for the transcription factor Haa1p, required for
Saccharomyces cerevisiae
response to acetic acid stress. Nucleic Acids Research, 16,
6896-907, 2011.
Teixeira,
M.C., Cabrito, T.R., Hanif, Z.M., Vargas, R.C.,
Tenreiro, S., Sá-Correia, I., Yeast response and tolerance to polyamine
toxicity involving the drug:H+
antiporter Qdr3 and the transcription factors Yap1 and
Gcn4. Microbiology, 157, 945-956, 2011
Teixeira
M.C., Mira N.P., Sá-Correia I., A genome-wide perspective on the response and
tolerance to food-relevant stresses in Saccharomyces
cerevisiae. Current Opinion in Biotechnology,
22:150-156, 2011 (abstract)
Abdulrehman
D., Monteiro P.T., Teixeira M.C., Mira N.P., Lourenço A.B., dos Santos S.C.,
Cabrito T.R., Francisco A., Madeira S.C., Santos R., Oliveira, A.L.,
Sá-Correia I., Freitas A. T., “YEASTRACT: Providing a programmatic access to
curated transcriptional regulatory associations in
Saccharomyces cerevisiae
through a web services interface". Nucleic Acids Research, 39,
D136-140, 2011
Sá-Correia I.,
Teixeira M.C., Two-dimensional Electrophoresis-based Expression Proteomics: a
microbiologist’s perspective. Expert Reviews of Proteomics, 7(6),
943-953, 2010 Teixeira M.C., Dias P.J., Monteiro P.T., Sala A., Oliveira A.L.,
Freitas A.T., Sá-Correia I., “Refining current knowledge on the yeast
FLR1 regulatory network by combined
experimental and computational approaches.” Molecular
Biosystems,
6(12), 2471-2481, 2010
Mira N.P., Teixeira M.C., Sá-Correia
I., “Adaptive response and tolerance to weak acids in
Saccharomyces cerevisiae
: a genome-wide view.”, OMICS: a Journal of Integrative Biology, 14(5),
525-540, 2010 (abstract)
Madeira S.,
Teixeira M.C., Sá-Correia I., Oliveira A.L., “Identification of
Regulatory Modules in Time Series Gene Expression Data using a Linear Time
Biclustering Algorithm”, IEEE/ACM Transactions
on Computational Biology and Bioinformatics, 7: 153-165, 2010
Teixeira M.C.,
Raposo L.R., Palma M., Sá-Correia I., 2010, "Identification of genes
required for maximal tolerance to high-glucose concentrations, as those
present in industrial alcoholic fermentation media, through a
chemogenomics approach", OMICS: A Journal of
Integrative Biology, 14(2), 201-210, 2010
Dias P.J.,
Teixeira M.C., Telo J.P., Sá-Correia I., 2010, "Insights into the
mechanisms of toxicity and tolerance to the agricultural fungicide
mancozeb in yeast, as suggested by a chemogenomic
approach", OMICS: A Journal of Integrative Biology, 14(2),
211-227, 2010
Teixeira
M.C., Raposo L.R., Mira N.P., Lourenço A.B., and Sá-Correia I.,
"Genome-wide identification of genes required for maximal tolerance to
ethanol in yeast: important role of FPS1" Applied
and Environmental
Microbiology, 75: 5761-5772, 2009
Teixeira M.C.,
Santos P.M., Rodrigues C., Sá-Correia I., “Teaching Expression Proteomics:
from the wet-lab to the laptop”, Biochemistry and Molecular Biology
Education, 37, 279-286, 2009
Cabrito T.R.,
Teixeira M.C., Duarte A.A., Duque P., Sá-Correia I., "Heterologous expression of a Tpo1 homolog from Arabidopsis
thaliana confers resistance to the herbicide 2,4-D and other chemical
stresses in yeast", Applied Microbiology and Biotechnology, 84,
927-936, 2009
Sá-Correia I., dos Santos S.C.,
Teixeira M.C., Cabrito T.R., Mira N.P., "Drug:H+ antiporters in chemical
stress response in yeast".
Trends in Microbiology, 17,
22-31, 2009 (abstract)
Teixeira M.C., Dias P.J., Simões T.,
Sá-Correia I. “Yeast adaptation to mancozeb
involves the up-regulation of FLR1 under the coordinate control of
Yap1, Rpn4, Pdr3 and Yrr1” Biochemical Biophysical Research Communications,
367, 249-255, 2008 (abstract)
Monteiro P., Mendes N., Teixeira M.C.,
d'Orey S., Tenreiro S., Mira N.P., Pais H.,
Francisco A., Carvalho A., Lourenço A.R., Sá-Correia I., Oliveira A.L.,
Freitas A.T. "YEASTRACT-DISCOVERER: new tools to improve the analysis of
transcriptional regulatory associations in Saccharomyces
cerevisiae". Nucleic Acids Research.
Database
Issue 36: D132-D136, 2008 (abstract)
Teixeira M.C., Duque P., Sá-Correia I.,
"Environmental Genomics: mechanistic insights into toxicity of and
resistance to the herbicide 2,4-D", Trends in Biotechnology, 25:
363-370, 2007 (abstract)
Vargas R.C., García-Salcedo
R., Tenreiro S., Teixeira M.C., Fernandes A.R., Ramos J., Sá-Correia
I., "Saccharomyces
cerevisiae multidrug resistance transporter Qdr2 is
implicated in potassium uptake, providing a physiological advantage to
quinidine-stressed cells" Eukaryotic Cell, 6,
134-142, 2007(abstract)
Teixeira M.C., Fernandes A.R., Mira
N.P., Becker J.D., Sá-Correia I., "Early transcriptional response of
Saccharomyces cerevisiae
to stress imposed by the herbicide 2,4-dichlorophenoxyacetic acid",
FEMS
Yeast Research, 6, 230–248, 2006 (abstract)
Teixeira M.C., Monteiro P., Jain P.,
Tenreiro S., Fernandes A.R., Mira N.P., Alenquer M.,
Freitas A.T., Oliveira A.L., Sá-Correia I., "The YEASTRACT database: a
tool for the analysis of transcriptional regulatory associations in
Saccharomyces cerevisiae",
Nucleic Acids Research, Database Issue, 34, D446-D451, 2006
(abstract)
Teixeira M. C., Santos P. M.,
Fernandes A. R., Sá-Correia I., "A proteome analysis of yeast responses
to the herbicide 2,4-dichlorophenoxyacetic acid",
Proteomics,
5,
1889-1901, 2005 (abstract).
Viegas C.A., Cabral M.G., Teixeira
M.C., Neumann G., Heipieper H.J., Sá-Correia I., Yeast
adaptation to 2,4-dichlorophenoxyacetic acid involves increased membrane
fatty acid saturation degree and decreased OLE1 transcription,
Biochemical and Biophysical
Research Communications, 330: 271-278, 2005
(abstract)
Tenreiro S., Vargas R.C., Teixeira
M.C., Magnani C., Sá-Correia I., "The yeast multidrug
transporter Qdr3 (Ybr043c): localization and role as a determinat
of resistance to quinidine, barban,
cisplatin and bleomycin",
Biochemical and Biophysical Research Communications, 327,
952-959, 2005 (abstract)
Teixeira M.C., Telo J.P., Duarte N.F.,
Sá-Correia I., "The herbicide 2,4-dichlorophenoxyacetic acid induces the
generation of free-radicals and associated oxidative stress responses in
yeast", Biochemical and Biophysical Research Communications, 324,
1101-1107, 2004 (abstract)
Vargas R.C., Tenreiro S., Teixeira
M.C., Fernandes A.R., Sá-Correia I., "Saccharomyces
cerevisiae multidrug transport Qdr2p
(Yil121wp): localization and function as a quinidine
resistance determinant", Antimicrobial Agents and Chemotherapy,
48, 2531-2537, 2004 (abstract)
Simões T., Teixeira M.C., Fernandes
A.R., Sá-Correia I., "Adaptation of Saccharomyces
cerevisiae to the herbicide 2,4-dichlorophenoxyacetic
acid, mediated by Msn2p- and Msn4p-regulated genes: important role of SPI
1", Applied and Environmental Microbiology, 69,
4019-4028, 2003 (abstract) Cabral
M.G., Viegas C.A., Teixeira M.C. and Sá-Correia I.
(2003),
"Toxicity of chlorinated phenoxyacetic acid
herbicides in the experimental eukaryotic model Saccharomyces
cerevisiae: role of pH and of growth phase and
size of the yeast cell population", Chemosphere, 51, 47-54
(abstract)
Teixeira, M. C., Sá-Correia, I.,
"Saccharomyces cerevisiae
resistance to chlorinated phenoxyacetic acid herbicides
involves Pdr1p–mediated transcriptional activation of
TPO1 and PDR5
genes", Biochemical
Biophysical Research Communications, 292, 530-537, 2002 (abstract)
Tenreiro,
S., Nunes, P. A., Viegas, C. A., Neves, M. S.,Teixeira,
M. C., Cabral, M. G., Sá-Correia, I., “AQR1
gene (ORF YNL065w) encodes a plasma
membrane transporter of the Major Facilitator Superfamily
that confers Resistance to Short-chain Monocarboxylic
Acids and Quinidine in
Saccharomyces cerevisiae”,
Biochemical and Biophysical Research
Communications,
292,
741-748, 2002 (abstract)
Papers in national journals with referees: Santos, P. M., Teixeira, M. C., Sá-Correia, I., “A Análise Proteómica Quantitativa na Revelação de Mecanismos de Resposta a stresse químico em microrganismos”, Boletim de Biotecnologia, 77:7-17, 2004.
Patents:
Papers
in conference proceedings:
dos Santos, S.C., Teixeira, M.C.,
Mira, N.P., Cabrito, T.R., Palma, M., Lourenco, A.B., Dias, P.J., Guerreiro,
J., Moreira, A., Henriques, S., Sá-Correia, I., "Response and resistance
to drugs and chemical stress in the yeast model: A genome-wide view",
Proceedings of the 1st Portuguese
meeting in Bioengineering, 1-4 March 2011, Oeiras,
Portugal (Portuguese chapter of IEEE EMBS).
Freitas, A.T., Ramalho, A. P.,
Oliveira C. A., Nogueira, C. S., Teixeira, M. C., Sá-Correia, I., Oliveira,
A. L., “Identification of cooperative mechanisms in transcription regulatory
networks using non-supervised learning techniques”, Workshop “Data Mining in Functional Genomics and
proteomics: Current Trends and Future Directions”, ECML/PKDD 2007. Monteiro, P., Teixeira, M. C., Jain, P., Tenreiro, S., Fernandes, A. R., Mira, N., Alenquer, M., Freitas, A. T., Oliveira, A. L., Sá-Correia, I., "YEASTRACT: a database of transcription regulatory associations in Saccharomyces cerevisiae", BKDB2005 - Bioinformatics for Knowledge Discovery in Biology, 17th of June Lisbon, Portugal (p 34-38; selected for oral presentation). |
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