INÊS NUNES SILVA

(Post-Doc Researcher) *

Alternative Pages: Google Scholar; Research ID; iBB webpage

 

Status at iBB - Institute for Bioengineering and Biosciences:

Education:

  • MSc in Biological Engineering, Instituto Superior Técnico, Technical University of Lisbon, Portugal, 2008

  • PhD in Biotechnology, Instituto Superior Técnico, Technical University of Lisbon, Portugal, 2012

Research Activities:

  • Relevance of phenotype switch in Burkholderia cepacia complex clinical isolates

Grants:

  • PhD Scholarship SFRH/BD/43939/2008, granted by FCT - Fundação para a Ciência e Tecnologia.

  • Post-doc Scholarship SFRH/BPD/86475/2012, granted by FCT - Fundação para a Ciência e Tecnologia.

 

Publications:

 

Theses

 

Silva IN (2008). Studies on the involvement of mucoid phenotype in bacteria from the Burkholderia cepacia complex: gene identification and microarray design. MSc Thesis, Instituto Superior Técnico, UTL, Lisbon, 2008

Papers in International Journals

Silva IN, Santos PM, Moreira LM., "Draft Genome Sequences of Two Burkholderia multivorans Sequential Isolates from a Chronic Lung Infection of a Cystic Fibrosis Patient", Genome Announc. 3(1). pii: e01531-14, 2015. 

Ferreira AS, Silva IN, Fernandes F, Pilkington R, Callaghan M, McClean S, Moreira LM. "The tyrosine kinase BceF and the phosphotyrosine phosphatase BceD of Burkholderia contaminans are required for efficient invasion and epithelial disruption of a cystic fibrosis lung epithelial cell line", Infect Immun. 83(2):812-21, 2015.

Silva IN, Tavares AC, Ferreira AS, Moreira LM., "Stress conditions triggering mucoid morphotype variation in Burkholderia species and effect on virulence in Galleria mellonella and biofilm formation in vitro",  PLoS One. 8(12):e82522, 2013. 

Ferreira AS, Silva IN, Oliveira VH, Becker JD, Givskov M, Ryan RP, Fernandes F, Moreira LM., "Comparative transcriptomic analysis of the Burkholderia cepacia tyrosine kinase bceF mutant reveals a role in tolerance to stress, biofilm formation, and virulence", Appl Environ Microbiol. 79(9):3009-20, 2013.

Silva IN, Ferreira AS, Becker JD, Zlosnik JE, Speert DP, He J, Mil-Homens D, Moreira LM., "Mucoid morphotype variation of Burkholderia multivorans during chronic cystic fibrosis lung infection is correlated with changes in metabolism, motility, biofilm formation and virulence", Microbiology. 157(Pt 11):3124-37, 2011.

Ferreira AS, Silva IN, Oliveira VH, Cunha R, Moreira LM., "Insights into the role of extracellular polysaccharides in Burkholderia adaptation to different environments", Front Cell Infect Microbiol. 1:16, 2011.

J.H. Leitão, S A Sousa, A.S. Ferreira, C.G. Ramos, I.N. Silva, L.M. Moreira. Pathogenicity, virulence factors, and strategies  to fight against Burkholderia cepacia complex pathogens and related  species. Applied Microbiology and Biotechnology. 87(1):31-40, 2010.

A.S. Ferreira, J.H. Leitão, I.N. Silva, P.F. Pinheiro, S.A. Sousa, C.G. Ramos, L.M. Moreira, Distribution of cepacian biosynthesis genes among environmental  and clinical Burkholderia strains and role of cepacian  exopolysaccharide in resistance to stress conditions. Applied and  Environmental Microbiology 76:441-450, 2010.

Oral Communications in International Scientific Meetings

Silva IN, Ferreira AS, Becker JD, Ramos CG, Mil-Homens D, Leitão JH, Fialho AM, Speert DP and Moreira LM.(2009). Phase variation in Burkholderia multivorans clinical isolates, 13th annual meeting of Burkholderia cepacia working group (IBCWG), Toronto, Canada.

Ferreira AS, Silva IN, Becker JD, Sousa SA, Mil-Homens D, Leitão JH, Fialho AM and Moreira LM.(2009). Cepacian biosynthesis in the Burkholderia genus: mechanisms and role in virulence, 13th annual meeting of Burkholderia cepacia working group (IBCWG), Toronto, Canada.