Dalila Mil-Homens

(Post-doc Researcher) *

Alternative Pages: Google Scholar; Researcher ID; iBB webpage

Status at iBB - Institute for Bioengineering and Biosciences:

·         Researcher of the Biological Sciences Research Group

Education:

·         Graduation in Chemical Engineering (Biotechnology), IST, UTL, Lisbon, Portugal, 1999

·         Master in Biotechnology (Biochemical Engineering), CEBQ/BSRG, IST, UTL, Lisbon, Portugal, 2007

·         PhD in Biotechnology, CEBQ/BSRG, IST, UTL, Lisbon, Portugal, 2012

Positions:

  • Post-doctoral fellow in the Biological Sciences Research Group, iBB - Institute for Bioengineering and Biosciences, Lisbon, Portugal, under the supervision of Professor Arsénio Fialho

Research Activities:

  • Comparative genomics for the identification of virulence factors in Burkholderia cenocepacia.
  • Molecular Biology of Burkholderia cenocepacia virulence factors

Grants:

·         PhD Scolarship from "Fundação para a Ciência e Tecnologia" (SFRH/BD/41760/2007)

Publications:

Thesis

Mil-Homens D, “Analysis of DNA repeats in the complete genome sequence of Burkholderia cenocepacia strain J2315 reveals the presence of novel putative virulence genes”, IST, UTL, Lisbon, 2007

 

Papers in international journals with referees

Mil-Homens D, Pinto SN, Matos RG, Arraiano C, Fialho AM, "Burkholderia cenocepacia K56-2 trimeric autotransporter adhesin BcaA binds TNFR1 and contributes to induce airway inflammation", Cellular Microbiology, doi: 10.1111/cmi.12677.

Santos R, Costa C, Mil-Homens D, Romão D, de Carvalho CCR, Pais P, Mira NP, Fialho AM, Teixeira MC,  The multidrug resistance transporters CgTpo1_1 and CgTpo1_2 play a role in virulence and biofilm formation in the human pathogen Candida glabrata", Cellular Microbiology, accepted for publication.

Moreira AS, Mil-Homens D*, Sousa SA*, Coutinho CP*, Pinto-de-Oliveira A, Ramos CG, dos Santos SC, Fialho AM, Leitão JH, Sá-Correia I, Variation of Burkholderia cenocepacia virulence potential during cystic fibrosis chronic lung infection. Virulence, doi:10.1080/21505594.2016.1237334 (in press).

Mil-Homens D, Ferreira-Dias S, Fialho AM, "Fish oils against Burkholderia and Pseudomonas aeruginosa: in vitro efficacy and their therapeutic and prophylactic effects on infected Galleria mellonella larvae", Journal of Applied Microbiology, 120(6):1509-19, 2016.

Viegas S., Mil-Homens D., Fialho A.M., Arraiano C.M. “The virulence of Salmonella Typhimurium in the insect model Galleria mellonella is impaired by mutations in endoribonucleases E and III” Applied and Environmental Microbiology, 79(19):6124-33, 2013

El-Kirat-Chatel S., Mil-Homens D., Beaussart A., Fialho A.M., Dufrêne Y.F. “Single-molecule atomic force microscopy unravels the binding mechanism of a Burkholderia cenocepacia trimeric autotransporter adhesin” Molecular Microbiology, 89(4):649-659, 2013

Mil-Homens D., Fialho A.M. “A BCAM0223 Mutant of Burkholderia cenocepacia is Deficient in Hemagglutination, Serum Resistance, Adhesion to Epithelial Cells and Virulence” PLoS One, 7(7):e41747, 2012

Mil-Homens D., Bernardes N., Fialho A.M. “The antibacterial properties of docosahexaenoic omega-3 fatty acid against the Cystic Fibrosis multi-resistant pathogen Burkholderia cenocepaciaFEMS Microbiology Letters 328(1):61-9, 2012. (abstract)

Mil-Homens D., Fialho A.M. “Trimeric autotransporter adhesins in members of the Burkholderia cepacia complex: a multifunctional family of proteins implicated in virulence” Frontiers in Cellular and Infection Microbiology 1:13, 2011. (abstract)

Rocha J., Popescu A.O., Borges P., Mil-Homens D, Sá-Correia I., Fialho A.M., Frazão C. “Burkholderia cepacia UDP-glucose dehydrogenase (BceC) structure and the role of Tyr10 in the final hydrolysis of UGDs thioester intermediate” Journal of Bacteriology, 193, 3978-3987, 2011.

Mil-Homens D.,  Rocha E.P.C., Fialho A.M., "Genome-wide analysis of DNA repeats of DNA repeats in Burkholderia cenocepacia J2315 identifies a novel adhesin-like gene unique to epidemic-associated strains of ET-12 lineage", Microbiology 156, 1084-1096, 2010. (abstract)

Holden MT, Seth-Smith HM, Crossman LC, Sebaihia M, Bentley SD, Cerdeño-Tárraga AM, Thomson NR, Bason N, Quail MA, Sharp S, Cherevach I, Churcher C, Goodhead I, Hauser H, Holroyd N, Mungall K, Scott P, Walker D, White B, Rose H, Iversen P, Mil-Homens D, Rocha EP, Fialho AM, Baldwin A, Dowson C, Barrell BG, Govan JR, Vandamme P, Hart CA, Mahenthiralingam E, Parkhill J."The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients." J Bacteriol. 2009,191(1):261-77.

Abstracts in international meetings

Mil-Homens D, Lajus A, Médigue C, Fialho AM, “Comparative genomics of Burkholderia species using the MaGe_BurkholScope genome browser”, International Burkholderia cepacia Working Group (IBCWG), Ca’ Tron di Roncade (Treviso), Italy, 14-17 April 2008

 Abstracts in national meetings

Mil-Homens D, Fialho AM, “Identification of a novel autotransporter adhesin cluster unique in the highly epidemic ET12 lineage of Burkholderia cenocepacia”, Poster S7/P11, MicroBiotec'07, 30/11 a 2/12, Lisbon, Portugal, 2007

Mil-Homens D, Lajus A, Médigue C, Fialho AM, “Comparative Pathogenomics of Burkholderia species”, First Portuguese Forum on Computational Biology, 10/7 a 12/7, Instituto Gulbenkian de Ciência, Oeiras, Portugal, 2008 

Mil-Homens D, Rocha EPC, Fialho AM, “Analysis of DNA repeats in the genome of Burkholderia cenocepacia J2315 reveals putative virulence genes that are unique in the higly epidemic ET-12 lineage”, Poster S2/P18, XVIth National Congress of Biochemistry, 22/10 a 25/10, Ponta Delgada, Portugal, 2008